Inhibiting macrophage PI3Kγ to enhance immunotherapy
نویسندگان
چکیده
منابع مشابه
The role of PI3Kγ in metabolism and macrophage activation
The class 1 phosphoinositide 3-kinase (PI3K) is a family of enzymes which add a phosphate group in position 3 to the membrane lipid phosphatidylinositol4,5-bisphosphate to generate the second-messenger phosphatidylinositol-3,4,5-trisphosphate. The class-1 PI3K family is further subdivided into class-1A and class1B. Class-1A PI3Ks comprises PI3Kα; PI3Kβ; and PI3Kδ, which are typically recruited ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2016
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2016.132